![]() ![]() Primary hyperaldosteronism can be caused by either hyperactivity in one adrenal gland (unilateral disease) or both (bilateral disease). Such changes may be cause, or consequence, of neuronal loss. ADHD is a neurodevelopment disorder characterized by a pattern of inattention and hyperactivity or impulsivity. Hyperaldosteronism: Hyperaldosteronism is a disease in which the adrenal glands make too much aldosterone, which leads to high blood pressure and low blood potassium levels. Our findings suggest that HPA axis hyperactivity in AD is associated with advancing age and cognitive dysfunction. Among AD subjects, AUC cortisol response correlated with current age ( r = 0♷0, P = 0♰01) and age at onset of dementia ( r = 0♷3, P = 0♰01) and an inverse correlation was seen between cortisol AUC and cognitive test (CAMCOG) score ( r = −0♵1, P = 0♰44). Similar findings have been reported to occur in depression. ![]() This shows that HPA axis hyperactivity, as demonstrated by enhanced adrenal sensitivity to ACTH, occurs in AD. Controlling for sex and medication, both peak cortisol level (peak–baseline) and area under cortisol response curve (AUC above baseline) were significantly greater in AD subjects. ![]() Adrenal sensitivity was assessed in 16 non-depressed patients with NINCDS/ADRDA Alzheimer's disease (AD) and 18 control subjects by measuring cortisol response to low dose (0♰5 μg/kg i.v.) exogenous adrenocorticotrophic hormone (ACTH). ![]()
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